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Journal of Clinical Endocrinology & Metabolism, Vol 49, 269-271, Copyright © 1979 by Endocrine Society

ARTICLES

Investigation of a corticosteroid-binding globulin-like molecule in human placenta

G Wolf and W Rosner

The existence of an endogenous corticosteroid-binding globulin (CBG)- like molecule in human placenta has been reported in studies which depended largely on immunological techniques. The experiments reported herein do not support that contention. Using a well characterized antibody to purified human CBG, we were unable to demonstrate CBG in placental cytosol. Although the immunological methods were too insensitive to detect CBG, the presence of small amounts of it were detected in binding experiments with [3H]cortisol. Simultaneous measurement of serum albumin indicated that the presence of CBG in the placental cytosol could be accounted for by contamination of the preparation with plasma.




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Copyright © 1979 by The Endocrine Society