help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lancranjan, I.
Right arrow Articles by Girard, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lancranjan, I.
Right arrow Articles by Girard, J.

Journal of Clinical Endocrinology & Metabolism, Vol 49, 227-230, Copyright © 1979 by Endocrine Society

ARTICLES

The alpha-adrenoceptor control of adrenocorticotropin secretion in man

I Lancranjan, E Ohnhaus and J Girard

Oral administration to six normal male volunteers of an alpha- adrenoceptor agonist, guanfacine (4 mg daily for 4 days) had no significant effect on ACTH release induced by metyrapone (a single oral 1-g dose). The same treatment with guanifacine significantly reduced ACTH secretion stimulated by insulin-induced hypoglycemia in another group of six male volunteers. These results indicate that, in man, the adrenergic system has an inhibitory input on stress-induced ACTY secretion via alpha-adrenoceptors. The concept of alpha-adrenergic control of ACTH secretion in man is in agreement with some experimental in vivo and in vitro data recorded in animals.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1979 by The Endocrine Society