help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Benveniste, R.
Right arrow Articles by Rabinowitz, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Benveniste, R.
Right arrow Articles by Rabinowitz, D.

Journal of Clinical Endocrinology & Metabolism, Vol 48, 883-886, Copyright © 1979 by Endocrine Society

ARTICLES

Circulating big human prolactin: conversion to small human prolactin by reduction of disulfide bonds

R Benveniste, JD Helman, DN Orth, TJ McKenna, WE Nicholson and D Rabinowitz

The heterogeneity of circulating human PRL (hPRL) in sera of patients with hyperprolactinemia was studied by exclusion chromatography on Sephadex G-100. Big hPRL, which elutes between the void volume and the elution position of monomeric small hPRL, is stable upon rechromatography but is almost entirely converted into small hPRL after reduction with 0.5% mercaptoethanol. These results suggest that the existence of circulating big hPRL is dependent upon the formation of interpolypeptide disulfide bonds and does not represent a classical biosynthetic precursor of hPRL.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
J. Gibney, T. P. Smith, and T. J. McKenna
The Impact on Clinical Practice of Routine Screening for Macroprolactin
J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 3927 - 3932.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1979 by The Endocrine Society