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Journal of Clinical Endocrinology & Metabolism Vol. 48, No. 4 715-717
doi:10.1210/jcem-48-4-715
Copyright © 1979 by the Endocrine Society.
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SPECIFIC CYTOSOL RECEPTORS FOR 1,25-DIHYDROXYVITAMIN D3 IN HUMAN INTESTINE

WAYNE R. WECKSLER*, REBECCA S. MASONt and ANTHONY W. NORMAN*

Department of Biochemistry, University of California, Riverside, California, 92521 and tDepartment of Medicine. Sidney Hospital, Sidney NSW 201, Australia.

Human intestine is shown to contain a specific, high affinity cytosol receptor or binding protein for 1,25-(OH)2 -vitamin D3 [1,25(OH)2 D3 ]. This receptor is a protein which sediments at 3.5S on sucrose gradients containing 0.3 M KC1. The receptor binds 1,25(OH)2 D3 with a Kd of approximately 2 x 10-10 M at 4°C. Competition binding studies using structural analogs of l,25(OH)2 D3 indicate that the relative specificity of the receptor is 1,25(OH)2 D3 > 1,24R,25(OH)3 D3 >> 25OHD3 1 OHD3 > 24R,25(OH)2 D3.

* August 21, 1978




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