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Acid-Ethanol-Extractable Nonsuppressible Insulin-Like Activity (NSILA-S) during Pregnancy and the Puerperium, and in Cord Serum at Term^*

RUSSELL C. FRANKLIN, ROGER J. PEPPERELL, GEORGE C. RENNIE and DONALD P. CAMERON

Medical Research Centre, Prince Henry's Hospital (R.C.F., G.C.R., D.P.C.), and the Department of Obstetrics and Gynecology, University of Melbourne (R.J.P.), Melbourne, Australia

A longitudinal study of serum NSILA-S during normal human pregnancy and the puerperium has demonstrated that levels rose progressively during pregnancy and returned to nonpregnant values about 48 h after delivery. Low concentrations were defined within the feto-placental circulation at term. Cord arterial and venous levels were equivalent, but there was no significant correlation between these and matched maternal values (J Clin Endocrinol Metab 48: 695, 1979)

^* This work was supported by a grant from the National Health and Medical Research Council of Australia.

Postgraduate Scholar, National Health and Medical Research Council of Australia.

Received July 31, 1978.