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Effect of Three Serotonin Antagonists on Plasma Prolactin Response to Suckling in Puerperal Women^*

Department of Obstetrics and Gynecology of the University of Milan Milan, Italy

Address requests for reprints to: Dr. P. G. Crosignani, Clinica Ostetrica e Ginecologica, Universita di Milano, 12 Via Commenda, 20122 Milano, Italy.

The effect of the acute administration of three serotonin antagonists on plasma PRL levels and on the PRL response to suckling was investigated in a group of puerperal women. A single oral dose of metergoline or methysergide induced a significant decrease of plasma PRL levels and abolished the PRL response to suckling. Cyproheptadine administration did not modify either the plasma PRL levels or the PRL response to suckling. These results are discussed in light of the known pharmacological properties of the three antiserotonergic drugs. (J Clin Endocrinol Metab 48: 335, 1979)

^* This work was supported by Grant 77.00328.85 from Consiglio Nazionale delle Ricerche, Rome (Special Project on Reproductive Biology).

Received May 2, 1978.