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Enhanced Adrenal Responsiveness to Angiotensin II in Patients with Low Renin Essential Hypertension^*

ALAN D MARKS, DAWN B MARKS, TERRY M KANEFSKY, VICTOR E ADLIN and BERTRAM J CHANNICK

Department of Medicine, Section of Endocrinology, Temple University Health Sciences Center Philadelphia, Pennsylvania 19140

The plasma aldosterone response to infused angiotensin II was determined in normal controls and in patients with normal renin and with low renin essential hypertension. The patients with low renin essential hypertension showed an enhanced plasma aldosterone response when compared to the other two groups. This finding may explain why plasma aldosterone levels remain within normal limits in the face of suppressed plasma renin and angiotensin II concentrations in low renin essential hypertension. (JClin Endocrinol Metab 48: 266, 1979)

^* This work was supported in part by an American Heart Association grant (Southeastern Pennsylvania Chapter) and Temple University Hospital General Clinical Research Center Grant 5M01RR349-11.

To whom requests for reprints should be addressed.

Received March 6, 1978.

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