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Endocrine Features of an Adrenal-Like Tumor of the Ovary^*

Division of Reproductive Endocrinology, Department of Gynecology and Obstetrics, and the Division of Pediatric Endocrinology, Department of Pediatrics, The Johns Hopkins University School of Medicine Baltimore, Maryland 21205

Address all correspondence and requests for reprints to: Dr. Peter A. Lee, CMSC 3-110, The Johns Hopkins Hospital, Baltimore, Maryland 21205.

Detailed in vivo endocrine studies of a virilizing adrenal-like tumor of the ovary are reported. A nonspecific steroidogenic baseline profile was observed in the face of clearcut histological adrenal-like features. Dynamic testing disclosed incomplete dexamethasone-related steroidogenic suppression suggestive of partial tumoral autonomy. At the same time, the observation of sizable dexamethasone-related steroidogenic decrements, unaccounted for by normal adrenal contribution, may be interpreted to suggest a direct, pharmacological, inhibitory effect of dexamethasone on tumoral and/or ovarian stromal steroidogenesis. These observations confirm the limited role of baseline steroid profiling and dynamic testing in the preoperative localization of androgen-secreting tumors. Reversible dysfunction of hypothalamic gonadotropic feedback mechanisms was suggested by combined single dose LRH-clomiphene testing. Complete resolution followed tumor removal. (J Clin Endocrinol Metab 48: 241, 1979)

^* Present address: Department of Reproductive Medicine, School of Medicine, University of California at San Diego La Jolla, California 92037

Received June 29, 1978.

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