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Carcinoma of the Breast Associated with Hypercalcemia and the Presence of Parathyroid Hormone-Like Substances in the Tumor^*

JANICE E.H HIRSHORN, ELIZABETH VRHOVSEK and SOLOMON POSEN

Department of Medicine, Sydney Hospital, Sydney, New South Wales Australia 2000

Address requests for reprints to: Dr. J. Hirshorn, Garvan Institute of Medical Research, St. Vincent's Hospital, Darlinghurst, New South Wales, Australia 2010.

A woman with metastatic carcinoma of the breast developed hypercalcemia 39 months after mastectomy. The hypercalcemia remitted after treatment but recurred 12 months later, accompanied by elevated levels of serum immunoreactive parathyroid hormone (PTH). A urea/HCl extract of hepatic metastases contained immunoreactive PTH, material which stimulated the resorption of fetal rat bone in tissue culture, and material which stimulated chick renal adenylate cyclase activity. These findings strongly suggest that this breast cancer produced a PTH-like substance. (J Clin Endocrinol Metab 48: 217, 1979)

^* This work was supported by the National Health and Medical Research Council of Australia and the New South Wales State Cancer Council.

Recipient of a Commonwealth Postgraduate Research Award

This article has been cited by other articles:

				R. C. Hickey, N. A. Samaan, and G. L. Jackson Hypercalcemia in Patients With Breast Cancer: Osseous Metastases, Hyperplastic Parathyroid Tissue, or Pseudohyperparathyroidism? Arch Surg, May 1, 1981; 116(5): 545 - 552. [Abstract] [PDF]