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Journal of Clinical Endocrinology & Metabolism, Vol 48, 114-118, Copyright © 1979 by Endocrine Society

ARTICLES

Circulating melatonin in man: episodic secretion throughout the light- dark cycle

U Weinberg, RD D'Eletto, ED Weitzman, S Erlich and CS Hollander

A sensitive and specific RIA for melatonin has been validated for human plasma. Five young adult men had plasma samples obtained every 20 min during two 24-h periods. One was a normal active period and the other a basal period with complete bed rest. Melatonin was found to be secreted episodically throughout the 24 h in each condition, with secretory episodes clearly present during the waking day in the presence of bright light.


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