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Journal of Clinical Endocrinology & Metabolism, Vol 47, 1141-1143, Copyright © 1978 by Endocrine Society

ARTICLES

Failure of somatostatin to affect human chorionic somatomammotropin and human chorionic gonadotropin secretion in vitro

C Macaron, M Kyncl, L Rutsky, B Halpern and J Brewer

The effect of somatostatin (SRIF) on human chorionic somatomammotropin (hCS) secretion was studied in human placental explants cultured in vitro. In the experimental flasks, SRIF was added in a concentration of 10, 100, and 1000 ng/ml media; hCS levels measured by RIA were not different from those found in the control flasks. In separate experiments, we investigated the action of SRIF on hCG secretion by a human malignant choriocarcinoma cell line maintained in tissue culture. SRIF (1000 ng/ml) did not inhibit basal or dibutyryl cAMP-induced stimulation of hCG secretion. These results suggest that somatostatin does not suppress hCS or hCG release in vitro from normal or malignant trophoblast, respectively.




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