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Journal of Clinical Endocrinology & Metabolism, Vol 47, 689-690, Copyright © 1978 by Endocrine Society

ARTICLES

Effect of pyridoxine on pituitary release of growth hormone and prolactin in childhood and adolescence

EO Reiter and AW Root

The dopamine agonist, pyridoxine, was administered to 10 children being evaluated for short stature. Serum GH and PRL responses were contrasted to those after insulin-induced hypoglycemia (ITT) and L-dopa administration. Levels of GH did not change after pyridoxine, but PRL fell (P less than 0.05) to 42% of the zero time concentration. Significant increments of GH occurred during ITT and after L-dopa, while PRL was suppressed to a greater extent by L-dopa. We conclude that pyridoxine is not useful in assessment of hypothalamic-pituitary function.


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S.-G. Ren and S. Melmed
Pyridoxal Phosphate Inhibits Pituitary Cell Proliferation and Hormone Secretion
Endocrinology, August 1, 2006; 147(8): 3936 - 3942.
[Abstract] [Full Text] [PDF]


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