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Journal of Clinical Endocrinology & Metabolism, Vol 47, 41-45, Copyright © 1978 by Endocrine Society

ARTICLES

Progestin binding in testes from three siblings with the syndrome of male pseudohermaphroditism with testicular feminization

JY Dube, P Chapdelaine, FT Dionne, D Cloutier and RR Tremblay

We have found a specific binding protein for synthetic progestins 6,7- [3H]methyltrienolone (R1881) and 17,21-dimethyl-19-norpregna-4,9-diene- 3,20-dione (R5020) and in the testis cytosol from three "sisters" with the complete form of the testicular feminization syndrome. The binding component sediments in the 8S region of sucrose gradients. It is saturable. The apparent affinity constant (Ka) for R5020 was determined in two cases and found to be 1.8 and 0.6 X 10(8) M-1. The number of binding sites calculated from Scatchard plots is relatively high: 572 and 826 fmol/mg protein. Competition studies indicate that this putative receptor is specific for natural and synthetic progestins but not for 5 alpha-dihydrotestosterone and cortisol. Similar progestin binding could not be found in normal human and rat testes.


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