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Journal of Clinical Endocrinology & Metabolism, Vol 47, 200-203, Copyright © 1978 by Endocrine Society

ARTICLES

Opiates, prolactin, and the dopamine receptor

G Tolis, R Dent and H Guyda

The administration of a dopamine antagonist, chlorpromazine, and two opiates, morphine and methadone, resulted in a significant rise in serum PRL within 90-150 min. Prior administration of dopamine receptor agonists (apomorphine, levodopa, aand bromocriptine) blocked this effect. In contrast, cyproheptadine, a serotonin antagonist, did not. We suggest that the opiates induce hyperprolactinemia in man via dopamine receptor blockade.


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J. Bennett and R. Whale
Galactorrhoea may be associated with methadone use.
BMJ, May 6, 2006; 332(7549): 1071 - 1071.
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