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Journal of Clinical Endocrinology & Metabolism, Vol 46, 766-769, Copyright © 1978 by Endocrine Society

ARTICLES

Reduction of testosterone to 5 alpha-dihydrotestosterone by human and rat uterine tissues

LI Rose, VV Reddy and R Biondi

Incubations of adult rat uterine tissue and human endometrial and myometrial homogenates with [1,2,6,7-3H]testosterone resulted in the formation of 5 alpha-[3H]dihydrotestosterone. The rat uterine homogenates showed higher activity than the minced tissue. The activity in human tissue was found to be less than rat tissue on a per unit weight basis. The human endometrium has been found to possess significantly higher activity than myometrium. These results support the hypothesis that androgens may exert their effect on uterus via 5 alpha-reduced metabolites.




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Copyright © 1978 by The Endocrine Society