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Journal of Clinical Endocrinology & Metabolism, Vol 46, 686-688, Copyright © 1978 by Endocrine Society

ARTICLES

Effect of intravenous pyridoxine on plasma prolactin in hyperprolactinemic subjects

AM Spiegel, SW Rosen, BD Weintraub and SP Marynick

Intravenous pyridoxine has been reported to lower plasma PRL in normal subjects and in patients with the amenorrhea-galactorrhea syndrome. We tested the effect of pyridoxine (300-mg iv bolus) on plasma PRL in nine patients with hyperprolactinemia due to a variety of causes. There was no effect of pyridoxine on elevated plasma PRL in any of the nine hyperprolactinemic subjects. The potential utility of pyridoxine in the long term treatment of the galactorhea-amenorrhea syndrome will require further study.




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Copyright © 1978 by The Endocrine Society