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Journal of Clinical Endocrinology & Metabolism, Vol 46, 653-657, Copyright © 1978 by Endocrine Society

ARTICLES

Increased serum thyroglobulin levels in patients with nontoxic goiter

V Pezzino, R Vigneri, S Squatrito, S Filetti, M Camus and P Polosa

Thyroglobulin (Tg) levels were found to be elevated in 30 to 35 patients with euthyroid sporadic goiter and in 15 of 37 patients with euthyroid endemic goiter. The elevated Tg levels in the goitrous patients did not correlate with either goiter size, TSH levels, or urinary iodine excretion, but did correlate with the triiodothyronine to thyroxine ratio. It was concluded, therefore, that in both sporadic and endemic euthyroid goiters, factors other than goiter size and TSH, such as hypoiodination of Tg may be responsible for the elevated Tg secretion.


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Relations between various measures of iodine intake and thyroid volume, thyroid nodularity, and serum thyroglobulin
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