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Journal of Clinical Endocrinology & Metabolism, Vol 46, 349-352, Copyright © 1978 by Endocrine Society

ARTICLES

Cyproheptadine treatment of Nelson's syndrome: restoration of plasma ACTH circadian periodicity and reversal of response to TRF

DT Krieger and EM Condon

Administration of cyproheptadine for four months to a patient with Nelson's Syndrome was associated with evidence of skin lightening, decreased plasma ACTH concentrations, return of a normal circadian periodicity of plasma ACTH concentrations, and lack of responsiveness of plasma ACTH concentrations to TRF administration, in contrast to the response seen in the untreated state.


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L. B. Mercado-Asis, J. A. Yanovski, H. L. Tracer, C. L. Chik, and G. B. Cutler Jr.
Acute Effects of Bromocriptine, Cyproheptadine, and Valproic Acid on Plasma Adrenocorticotropin Secretion in Nelson's Syndrome
J. Clin. Endocrinol. Metab., February 1, 1997; 82(2): 514 - 517.
[Abstract] [Full Text] [PDF]


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