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Journal of Clinical Endocrinology & Metabolism, Vol 46, 8-14, Copyright © 1978 by Endocrine Society

ARTICLES

The mechanism of ovulation inhibition by triamcinolone acetonide

GR Cunningham, JW Goldzieher, A de la Pena and M Oliver

A single dose of 25 mg triamcinolone acetonide, when given on day 1 or 2 of the menstrual cycle, inhibits ovulation. To examine the mechanism of this action, daily determinations of plasm FSH, LH, estrone plus estradiol (E1 + E2), and progestins were performed. Some subjects also received a single dose of LH-RH or hCG on cycle day 15 or clomiphene citrate on days 5-9. Triamcinolone acetonide itself caused variable suppression of plasma estrogens, loss of the mid-cycle gonadotropin surge, and a deficient or absent rise in plasma progestins. Impaired secretion of estrogen did not seem to be due to low gonadotropin levels. FSH and LH responses to LH-RH were adequate in relation to prevailing estrogen levels. Four of six women treated with clomiphene responded with plasma progestin levels which exceed 8 ng/ml. Triamcinolone acetonide seems to affect the hypothalamic-pituitary- ovarian axis mainly by hypothalamic suppression and possibly by a direct effect on the ovary as well.


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 Ann Rheum DisHome page
J. M A MENS, A N. DE WOLF, B. J BERKHOUT, and H. J STAM
Disturbance of the menstrual pattern after local injection with triamcinolone acetonide
Ann Rheum Dis, November 1, 1998; 57(11): 700 - 700.
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