Journal of Clinical Endocrinology & Metabolism, Vol 46, 146-152, Copyright © 1978 by Endocrine Society

ARTICLES

Aromatization of androgens by muscle and adipose tissue in vivo

C Longcope, JH Pratt, SH Schneider and SE Fineberg

[7-3HA1Androstenedione and [4-14C]estrone or [7-3H]testosterone and [14C]estradiol were infused at constant rates into brachial arm veins of 15 normal men. During the infusions blood samples were obtained from the brachial artery, a deep vein draining primarily muscle, and a superficial vein draining primarily adipose tissue of the arm contralateral to the infusion. In seven men the mean +/- SE value for the fractional conversion of androstene tissue. In eight men the mean +/- SE value for the fractional conversion of testosterone to estradiol was 0.0007 +/- 0.0001 for muscle and 0.0012 +/- 0.0002 for adipose tissue. Both of these values were significantly (P less than 0.01) less than the respective values of androstenedione aromatization to estrone. If constancy of tissue aromatization throughout the body is assumed, the muscle accounts for 25-30% and adipose tissue for 10-15% of the total extragonadal aromatization of androgens to estrogens.

This article has been cited by other articles:

				K Larsson, D Mellstrom, C Nordborg, A Oden, and E Nordborg Early menopause, low body mass index, and smoking are independent risk factors for developing giant cell arteritis Ann Rheum Dis, April 1, 2006; 65(4): 529 - 532. [Abstract] [Full Text] [PDF]

				W. de Ronde, A. Hofman, H. A P Pols, and F. H de Jong A direct approach to the estimation of the origin of oestrogens and androgens in elderly men by comparison with hormone levels in postmenopausal women Eur. J. Endocrinol., February 1, 2005; 152(2): 261 - 268. [Abstract] [Full Text] [PDF]

				M. L. Kanchuk, R. C. Backus, C. C. Calvert, J. G. Morris, and Q. R. Rogers Weight Gain in Gonadectomized Normal and Lipoprotein Lipase-Deficient Male Domestic Cats Results from Increased Food Intake and Not Decreased Energy Expenditure, J. Nutr., June 1, 2003; 133(6): 1866 - 1874. [Abstract] [Full Text] [PDF]

				R. Kaaks, A. Lukanova, and M. S. Kurzer Obesity, Endogenous Hormones, and Endometrial Cancer Risk: A Synthetic Review Cancer Epidemiol. Biomarkers Prev., December 1, 2002; 11(12): 1531 - 1543. [Abstract] [Full Text] [PDF]

				S. L. Hui, A. J. Perkins, L. Zhou, C. Longcope, M. J. Econs, M. Peacock, C. McClintock, and C. C. Johnston Jr. Bone Loss at the Femoral Neck in Premenopausal White Women: Effects of Weight Change and Sex-Hormone Levels J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1539 - 1543. [Abstract] [Full Text] [PDF]

				C. E. Broeder, J. Quindry, K. Brittingham, L. Panton, J. Thomson, S. Appakondu, K. Breuel, R. Byrd, J. Douglas, C. Earnest, et al. The Andro Project: Physiological and Hormonal Influences of Androstenedione Supplementation in Men 35 to 65 Years Old Participating in a High-Intensity Resistance Training Program Arch Intern Med, November 13, 2000; 160(20): 3093 - 3104. [Abstract] [Full Text] [PDF]

				A. W. van den Beld, F. H. de Jong, D. E. Grobbee, H. A. P. Pols, and S. W. J. Lamberts Measures of Bioavailable Serum Testosterone and Estradiol and Their Relationships with Muscle Strength, Bone Density, and Body Composition in Elderly Men J. Clin. Endocrinol. Metab., September 1, 2000; 85(9): 3276 - 3282. [Abstract] [Full Text]

				N. Mauras, K. O. O’Brien, K. O. Klein, and V. Hayes Estrogen Suppression in Males: Metabolic Effects J. Clin. Endocrinol. Metab., July 1, 2000; 85(7): 2370 - 2377. [Abstract] [Full Text]

				P. A. Thompson and C. Ambrosone Chapter 7: Molecular Epidemiology of Genetic Polymorphisms in Estrogen Metabolizing Enzymes in Human Breast Cancer J Natl Cancer Inst Monographs, July 1, 2000; 2000(27): 125 - 134. [Abstract] [Full Text] [PDF]

				R. J. Pauley, S. J. Santner, L. R. Tait, R. K. Bright, and R. J. Santen Regulated CYP19 Aromatase Transcription in Breast Stromal Fibroblasts J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 837 - 846. [Abstract] [Full Text]

				I. Kato, P. Toniolo, A. Zeleniuch-Jacquotte, R. E Shore, K. L Koenig, A. Akhmedkhanov, and E. Riboli Diet, smoking and anthropometric indices and postmenopausal bone fractures: a prospective study Int. J. Epidemiol., February 1, 2000; 29(1): 85 - 92. [Abstract] [Full Text] [PDF]

				D. S. King, R. L. Sharp, M. D. Vukovich, G. A. Brown, T. A. Reifenrath, N. L. Uhl, and K. A. Parsons Effect of Oral Androstenedione on Serum Testosterone and Adaptations to Resistance Training in Young Men: A Randomized Controlled Trial JAMA, June 2, 1999; 281(21): 2020 - 2028. [Abstract] [Full Text] [PDF]

				H. Sasano and N. Harada Intratumoral Aromatase in Human Breast, Endometrial, and Ovarian Malignancies Endocr. Rev., October 1, 1998; 19(5): 593 - 607. [Abstract] [Full Text]

				E. S. Sher, C. J. Migeon, and G. D. Berkovitz Evaluation of Boys with Marked Breast Development at Puberty Clinical Pediatrics, June 1, 1998; 37(6): 367 - 371. [Abstract] [PDF]

				J. A. Langlois, M. Visser, L. S. Davidovic, S. Maggi, G. Li, and T. B. Harris Hip Fracture Risk in Older White Men Is Associated With Change in Body Weight From Age 50 Years to Old Age Arch Intern Med, May 11, 1998; 158(9): 990 - 996. [Abstract] [Full Text] [PDF]

				P. E. Mullis, N. Yoshimura, B. Kuhlmann, K. Lippuner, P. Jaeger, and H. Harada Aromatase Deficiency in a Female Who Is Compound Heterozygote for Two New Point Mutations in the P450arom Gene: Impact of Estrogens on Hypergonadotropic Hypogonadism, Multicystic Ovaries, and Bone Densitometry in Childhood J. Clin. Endocrinol. Metab., June 1, 1997; 82(6): 1739 - 1745. [Abstract] [Full Text] [PDF]