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Journal of Clinical Endocrinology & Metabolism, Vol 45, 1305-1309, Copyright © 1977 by Endocrine Society

ARTICLES

Effect of starvation on the production and metabolism of thyroxine and triiodothyronine in euthyroid obese patients

AG Vagenakis, GI Portnay, JT O'Brian, M Rudolph, RA Arky, SH Ingbar and LE Braverman

The metabolic clearance and production rates of thyroxine (T4) and triiodothyronine (T3) were measured in 9 obese euthyroid patients prior to and during prolonged starvation. The metabolic clearance rates (MCR) and serum concentrations of T4, and, therefore, the metabolic degradation or production rates of T4 were undecreased strikingly during starvation, from 145 +/- 7 ng/dl (mean +/- SE) to 66 +/- 9 ng/dl (P less than 0.001), while the mean MCR of T3 was unchanged, with the result that T3 degradation or production rates were markedly decreased (36.4 +/- 4.5 microgram/d vs. 11.2 +/- 0.7 microgram/d; P less than 0.001). These findings suggest that the decrease in serum T3 concentration observed during starvation results from a decrease in the peripheral conversion of T4 to 53.


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