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Journal of Clinical Endocrinology & Metabolism, Vol 45, 1235-1237, Copyright © 1977 by Endocrine Society

ARTICLES

Cyproheptadine inhibition of stimulated plasma renin activity

S Epstein and S Hamilton

Plasma renin activity (PRA) was stimulated by oral frusemide (60 mg) in 4 normal male subjects. Cyproheptadine (Periactin), a serotonin antagonist, was then administered (2 mg orally four times daily) for 7 days and the PRA response to frusemide re-evaluated in the 4 subjects. A highly significant mean inhibition (P less than 0.01) of frusemide stimulated PRA was demonstrated after cyproheptadine administration. Our results show that serotonin, presumably acting via central pathways, may play a role in renin regulation and that this pathway can be inhibited by cyproheptadine.




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Copyright © 1977 by The Endocrine Society