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Journal of Clinical Endocrinology & Metabolism, Vol 45, 1220-1223, Copyright © 1977 by Endocrine Society

ARTICLES

Serum albumin and antibodies in the diagnosis of thyroid cancer

LJ DeGroot, K Hoye, S Refetoff, AJ Van Herle, GT Asteris and H Rochman

Anti-thyroglobulin antibodies, anti-thyroid microsomal antibodies, serum thyroglobulin, and carcinoembryonic antigen were assayed in sera of patients with a history of thyroid irradiation and in patients with thyroid cancer. In irradiated patients, the frequency of positive results for each test was increased above the frequency found in a control population, with a significant increase at P less than .05 for TGHA and TG levels. However, the tests (with the exception of serum thyroglobulin) did not clearly segregate irradiated patients with benign or malignant lesions from those with no clinically detectable abnormalities. Elevations of serum thyroglobulin above 300 ng/ml were found only in patients with thyroid cancer, but in these patients the diagnosis was usually clinically obvious.


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K. Boelaert, J. Horacek, R. L. Holder, J. C. Watkinson, M. C. Sheppard, and J. A. Franklyn
Serum Thyrotropin Concentration as a Novel Predictor of Malignancy in Thyroid Nodules Investigated by Fine-Needle Aspiration
J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4295 - 4301.
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