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Journal of Clinical Endocrinology & Metabolism, Vol 45, 1159-1164, Copyright © 1977 by Endocrine Society

ARTICLES

Anti-insulin IgE in diabetics

D Kumar

Anti-insulin IgE and IgG were estimated in sera of diabetic patients. Using a paper radioimmunosorbent technique, detectable titers of anti- insulin IgE were found in all insulin-treated diabetics who were non- allergic to insulin. Patients with generalized insulin allergy, and immune-type insulin-resistance had higher titers of anti-insulin IgE. Anti-insulin IgG was present in all insulin-treated patients. The titers were significantly higher in insulin-resistant diabetics. Four of the 12 cases with insulin allergy had undetectable anti-insulin IgG titers. The ratios of 125I-insulin bound by IgE and IgG were significantly higher in 11 (91%) patients with systemic insulin- allergy. It is suggested that a relative excess of anti-insulin IgE may be associated with the insulin allergic state.


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S. E. Fineberg, T. T. Kawabata, D. Finco-Kent, R. J. Fountaine, G. L. Finch, and A. S. Krasner
Immunological Responses to Exogenous Insulin
Endocr. Rev., October 1, 2007; 28(6): 625 - 652.
[Abstract] [Full Text] [PDF]


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