Journal of Clinical Endocrinology & Metabolism, Vol 45, 1124-1127, Copyright © 1977 by Endocrine Society

ARTICLES

Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity

Y Harano, S Ohgaku, H Hidaka, K Haneda, R Kikkawa, Y Shigeta and H Abe

Glucose, insulin and somatostatin infusion over 2 hours effectively suppressed endogenous secretion of insulin, glucagon and growth hormones. Steady state plasma glucose level (SSPG) which should be inversely proportional to insulin sensitivity was obtained. In 6 adult- onset non-obese untreated diabetics, mean value of insulin sensitivity indices was significantly reduced compared with normal. In 5 insulin- treated diabetics and in 5 subjects with borderline glucose tolerance including 2 obese subjects, insulin sensitivity for glucose utilization was also significantly diminished.

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