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Journal of Clinical Endocrinology & Metabolism, Vol 45, 1120-1123, Copyright © 1977 by Endocrine Society

ARTICLES

Metabolism of catechol estrogen by human erythrocytes

GW Bates, CD Edman, JC Porter and PC MacDonald

In a study designed to evaluate the kinetics of catechol estrogen formation from plasma estrone in vivo, we obtained evidence that the red blood cell (RBC) enzyme, catechol-O-methyl transferase, catalyzes the transformation of 2-hydroxyestrone to 2-methoxyestrone. Under in vitro conditions, the rate of conversion of 2-hydroxyestrone to 2- methoxyestrone by human RBC's was such that 7 nmol of 2-methoxyestrone were formed per h per ml of RBC.




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Copyright © 1977 by The Endocrine Society