Journal of Clinical Endocrinology & Metabolism, Vol 45, 1049-1052, Copyright © 1977 by Endocrine Society
Benign breast dysplasia causing hypercalcemia
SJ Marx, RM Zusman and WO Umiker
An adolescent female had hypercalcemia and massive, bilateral breast
enlargement. At neck and mediastinal explorations three parathyroid glands
were removed and found to be histologically normal. Following bilateral
mastectomy the hypercalcemia resolved within two days and did not recur
during a six-year period of followup. Microscopic examination of the
excised breast tissue revealed marked dysplasia but no cancer. Those
findings suggest that benign, dysplastic breast tissue can release humoral
mediators of hypercalcemia.