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*PYRIDOXINE HYDROCHLORIDE

Journal of Clinical Endocrinology & Metabolism, Vol 45, 1019-1022, Copyright © 1977 by Endocrine Society

ARTICLES

Suppression of thyrotropin (TSH) and prolactin (PRL) release by pyridoxine in chronic primary hypothyroidism

G Delitala, P Rovasio and G Lotti

A single iv dose of pyridoxine (V) (300 mg) caused a significant decrease in the concentration of serum thyrotropin (TSH) in 6 patients with primary hypothyroidism. There was no consistent change in serum thyroxine and triiodothyronine concentrations suring the experiment. The serum prolactin (PRL) levels were also suppressed by pyridoxine administration. These findings suggest that pyridoxine inhibits TSH secretion as well PRL by a direct action on the hypothalamus or pituitary gland.




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Copyright © 1977 by The Endocrine Society