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Journal of Clinical Endocrinology & Metabolism, Vol 45, 845-848, Copyright © 1977 by Endocrine Society

ARTICLES

Decreased cortical thickness & osteopenia in children with diabetes mellitus

JV Santiago, WH McAlister, SK Ratzan, Y Bussman, MW Haymond, G Shackelford and VV Weldon

A recent study using the photon absorption technique has revealed a high frequency of significant bone loss in diabetic adults regardless of age or duration of diabetes. In this study 107 diabetic children age 4-18 were studied using cortical bone thickness and skeletal maturation as indicators of bone development. Overall, 25% of all diabetic children had cortical thickness values below the five percent limit for normal children. This was more common in boys than girls and was unrelated to duration of diabetes. A modest increase in delayed skeletal maturation did not account for the cortical thinning and osteopenia observed. The cause of the osteopenia of diabetic children remains an enigma.


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