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Journal of Clinical Endocrinology & Metabolism, Vol 45, 828-832, Copyright © 1977 by Endocrine Society

ARTICLES

Serum somatomedin peptides measured by somatomedin A radioreceptor assay in chronic liver disease

K Takano, N Hizuka, K Shizume, N Hayashi, Y Motoike and H Obata

The levels of serum somatomedin peptides were determined with a somatomedin A radioreceptor assay utilizing human placental membranes. Low levels were found in 25 patients with liver cirrhosis and 28 patients with chronic hepatitis with the mean of 0.47 +/- 0.05 and 0.60 +/- 0.04 U/ml, respectively. There was a positive correlation between somatomedin A on one hand and serum albumin, cholinesterase, total cholesterol and thrombotest on the other. There was a negative correlation between somatomedin A and the indocyanine green retention test. These findings confirm earlier results obtained with bioassay.




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Copyright © 1977 by The Endocrine Society