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Journal of Clinical Endocrinology & Metabolism, Vol 45, 367-370, Copyright © 1977 by Endocrine Society

ARTICLES

Cimetidine, an H2-antihistamine, stimulates prolactin secretion in man

HE Carlson and AF Ippoliti

Intravenous administration of cimetidine, a histamine (H2) receptor antagonist, provoked an immediate 2 to 3-fold rise in serum prolactin concentrations in 8 normal men; serum thyrotropin, growth hormone, thyroxine, and triiodothyronine were not significantly affected. Diphenhydramine, an H1-antagonist, was without effect on any of the hormones measured. The results suggest that histamine may have an important function in the regulation of prolactin secretion in man.




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Copyright © 1977 by The Endocrine Society