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Journal of Clinical Endocrinology & Metabolism, Vol 45, 293-298, Copyright © 1977 by Endocrine Society

ARTICLES

The influence of beta-adrenoceptor blocking agents on plasma thyroxine and triiodothyronine

WM Wiersinga and JL Touber

The effect of the beta-adrenoceptor blocking agent propranolol on plasma levels of thyroxine and triiodothyronine was studied in eleven hyperthyroid patients and in six hypothyroid patients on L-thyroxine substitution therapy. In all patients a decrease in plasma- triiodothyronine was found. The per cent decrease of plasma- triiodothyronine was the same in both groups. Plasma levels of thyroxine and thyrotropin increased in the hypothyroid patients, but remained constant in the hyperthyroid subjects. The decrease in plasma- triiodothyronine during propranolol medication is most likely caused by an inhibition of the peripheral conversion of thyroxine into triiodothyronine.




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Copyright © 1977 by The Endocrine Society