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Journal of Clinical Endocrinology & Metabolism, Vol 45, 86-94, Copyright © 1977 by Endocrine Society

ARTICLES

Hypercalcemic hyperparathyroidism in hypophosphatemic rickets

M Kleerekoper, R Coffey, T Creco, S Nichols, N Cooke, W Murphy and LV Avioli

A 25-year-old white woman with sporadic hypophosphatemic rickets presented with a 7 year history of chronic mild hypercalcemia, osteitis fibrosa cystic and hypercalcemic nephropathy. Serum immunoreactive parathyroid hormone was elevated by greater than 100-fold and a 3.5 g parathyroid tumor was found at operation. Survey of the literature reveals that of 9 previous cases in which hypercalcemic hyperparathyroidism occurred in association with hypophosphatemic rickets, only two had classical x-linked familial hypophosphatemic rickets. It appears more than likely that this unusual combination of skeletal diseases represents the chance occurrence of primary hyperparathyroidism in patients with underlying x-linked familial hypophosphatemic rickets rather than a complication of phosphate therapy.


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R. M. Savio, J. E. Gosnell, S. Posen, T. S. Reeve, and L. W. Delbridge
Parathyroidectomy for Tertiary Hyperparathyroidism Associated With X-linked Dominant Hypophosphatemic Rickets
Arch Surg, February 1, 2004; 139(2): 218 - 222.
[Abstract] [Full Text] [PDF]


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