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Journal of Clinical Endocrinology & Metabolism Vol. 44, No. 6 1222-1225
doi:10.1210/jcem-44-6-1222
Copyright © 1977 by the Endocrine Society.
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EFFECT OF PROLACTIN ON PLASMA DHEA(S) LEVELS

Alex Vermeulen, Edward Suy* and Robert Rubens

Departments of Endocrinology and Metabolism, Academic Hospital Rijksuniversiteit, 9000 Ghent, Belgium
* Psychiatric Institutes Mater Dei Sleidinge, Belgium.

Plasma DHEA and DHEA-S levels were significantly higher (P < 0.001) in women with elevated prolactin levels, due either to chronic treatment with psychotropic drugs or to a prolactinoma, than in untreated controls. This increase was also observed in 3 male patients with prolactinoma. It is suggested that this increase is the consequence of a direct effect of prolactin on the adrenal cortex and that prolactin might be responsible for the ACTH independent adrenocortical androgen secretion.

Supported by grant n°. 20.477 from the F.W.G.O.

Received March 3, 1977.




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Copyright © 1977 by The Endocrine Society