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Plasma 17-Hydroxyprogesterone in Spironolactone-Treated Hypertensives

Department of Internal Medicine, Medical College of Ohio Toledo, Ohio

Reprint requests to: Dr. S. Y. Tan, Department of Internal Medicine, Medical College of Ohio, P.O. Box 6190, Toledo, Ohio 43614.

When measured by a specific radioassay method which excludes drug interference, plasma 17-hydroxyprogesterone levels were found to be similar in spironolactone treated hypertensives, in untreated hypertensives, and in normotensive volunteers. No in vivo evidence for a significant inhibitory effect of spironolactone on adrenal 11β, 17 and 21 hydroxylases was uncovered.

Nomenclature: Spironolactone: 17β-hydroxy-7-acetylthio-3-oxo-pregn-4-ene-21-carboxylic acid, lactone; Canrenone: 17β-hydroxy-3-oxo-pregna-4, 6-diene-21-carboxylic acid, lactone; K% Canrenoate: 17β-hydroxy-3-oxo-pregna-4, 6-diene-21-carboxylic acid, potassium salt; Metabolite X: 6β, 17β-dihydroxy-7-methylsulfinyl-3-oxo-pregn-4-ene-21-carboxylic acid, lactone; SC 26519: 17β-hydroxy-7-methylthio-3-oxo-pregn-4-ene-21-carboxylic acid, lactone; SC 26780: 17β-hydroxy-7-methylsulfinyl-3-oxo-pregn- 4-ene-21-carboxylic acid, lactone; SC 24813: 17β-hydroxy - 7 - mercapto - 3 - oxo - pregn - 4 - ene - 21-carboxylic acid, lactone.

Received February 17, 1976.