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Journal of Clinical Endocrinology & Metabolism, Vol 44, 1200-1202, Copyright © 1977 by Endocrine Society

ARTICLES

Plasma 17alpha-hydroxyprogesterone in spironolactone-treated hypertensives

SY Tan and PJ Mulrow

When measured by a specific radio-assay method which excludes drug interference, plasma 17alpha-hydroxyprogesterone levels were found to be similar in spironolactone treated hypertensives, in untreated hypertensives, and in normotensive volunteers. No in vivo evidence for a significant inhibitory effect of spironolactone on adrenal 11beta, 17alpha and 21 hydroxylases was uncovered.




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Copyright © 1977 by The Endocrine Society