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Ineffectiveness of Pyridoxine (B₆) to Alter Secretion of Growth Hormone and Prolactin and Absence of Therapeutic Effects on Galactorrhea-Amenorrhea Syndromes

¹ Departments of Medicine, McGill University, Royal Victoria Hospital, Montreal, Canada
² Departments of Obstetrics and Gynecology, McGill University, Royal Victoria Hospital Montreal, Canada

The acute effect of pyridoxine (B₆) on serum GH and PRL levels and its chronic effects on galactorrhea in nine subjects (group I, n = 4, idiopathic galactorrhea with normal PRL levels and normal menses; Group II, n = 5, galactorrheaamenorrhea with increased PRL levels) have been studied. Pyridoxine did not acutely alter GH or PRL levels. There was no decrease in galactorrhea, no resumption of menses and no decrease in PRL following two months of B₆ therapy. In contrast, bromocriptine was effective in suppressing galactorrhea and restoring normal menses in group II subjects and remains the therapy of choice for this purpose.

Supported by the Quebec Research Council G.T- 750101 and the Medical Research Council of Canada HG, MT-4403; FN MT-5823.

Received November 2, 1976.

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