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Journal of Clinical Endocrinology & Metabolism, Vol 44, 1190-1193, Copyright © 1977 by Endocrine Society

ARTICLES

Increased plasma 11-deoxycorticosterone during spironolactone medication

U Abshagen, S Sporl, M Schoneshofer and W Oelkers

The increase of plasma deoxycorticosterone (DOC) levels after administration of spironolactone is a real effect and not due to cross- interference of the drug or its metabolites with the DOC-assay. This is proved by in vitro and in vivo results. Of all the metabolites only canrenone interferes to some extent with DOC after liquid-liquid- extraction and paper chromatography. The antiserum, however, is so highly specific, that the final cross-interference of the total procedure amounts to less than 2% of the DOC plasma levels. Moreover, in patients with Addison's disease only a very small increase of DOC plasma levels can be observed after administration of spironolactone in contrast to normal subjects.




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Copyright © 1977 by The Endocrine Society