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The Binding of a Synthetic Progestin, R5020, to Transcortin and Serum Albumin

Departments of Biochemistry and Pediatrics, Schools of Medicine and Dentistry, State University of New York at Buffalo, Buffalo New York

R5020 (17,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione), a synthetic progestin, was tested for its binding to purified human transcortin, albumin and human serum. Scatchard analysis showed that R5020 bound relatively weakly to transcortin (Kass= 8x10⁶M^–1); in 20% human serum or albumin greater than 90%was bound with low Kass and an indeterminate number of binding sites.

Supported in part by U.S.P.H.S. grant GM21045.

Received October 20, 1976.

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