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Journal of Clinical Endocrinology & Metabolism Vol. 44, No. 5 980-983
doi:10.1210/jcem-44-5-980
Copyright © 1977 by the Endocrine Society.
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Comparison of Serum Calcitonin Levels After a 1-Minute Calcium Injection and After Pentagastrin Injection in the Diagnosis of Medullary Thyroid Carcinoma

ROBERT K. RUDE and FREDERICK R. SINGER

Department of Medicine, University of Southern California School of Medicine, Los Angeles California 90033

Reprint requests to Robert K. Rude, M.D., Department of Medicine, University of Southern California School of Medicine, 2025 Zonal Avenue, Los Angeles, California 90033.

1-min calcium injection was compared with a pentagastrin injection as provocative measures in stimulating calcitonin secretion in 4 patients with medullary thyroid carcinoma. In all cases the calcium injection resulted in a greater rise in serum calcitonin concentration. The patients tolerated the calcium injection well. However, two patients experienced substemal pressure and dyspnea following the pentagastrin injection. It is concluded that a 1-min calcium injection is a safe, rapid and effective procedure in the diagnosis of medullary thyroid carcinoma.

Supported in part by USPHS GCRC grant RR-43.

Received October 12, 1976.




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