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Journal of Clinical Endocrinology & Metabolism, Vol 44, 977-979, Copyright © 1977 by Endocrine Society

ARTICLES

Adrenergic modulation of growth hormone secretion in acromegaly: alpha- and beta-adrenergic blockade produce qualitatively normal responses but no effect on L-dopa suppresion

PE Cryer and WH Daughaday

The serum GH response to oral L-Dopa during the separate infusions of saline, phentolamine and propranolol was exmined in 12 acromegalic patients. In six L-Dopa responsive patients, serum GH concentrations rose during propranolol infusions (and fell during phentolamine infusions as previously reported). There was no effect of propranolol or phentolamine on the fall in serum GH following oral L-Dopa in this group of patients. Thus, beta-adrenergic, as well as alpha-adrenergic, mechanisms are involved to the regulation of GH secretion in a qualitatively normal fashion in some acromegalic patients. However, the qualitatively abnormal suppressive effect of L-Dopa on GH secretion seen in some acromegalic patients does not appear to be mediated through either alpha-adrenergic or beta-adrenergic mechanisms.




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Copyright © 1977 by The Endocrine Society