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Journal of Clinical Endocrinology & Metabolism, Vol 44, 884-891, Copyright © 1977 by Endocrine Society

ARTICLES

MSH/ACTH 4-10 influences behavioral and physiological measures of attention

CA Sandman, J George, TR McCanne, JD Nolan, J Kaswan and AJ Kastin

Eleven healthy male volunteers were infused with MSH/ACTH 4-10 and a control solution in a completely crossed and balanced procedure. Perception, attention and memory were tested as were heart rate and cephalic pulse amplitude in response to changes in the environment. Treatment of subjects with MSH/ACTH 4-10 raised their perceptual threshold for detection of simple stimuli and facilitated perceptual integration of patterned information. Administration of the heptapeptide improved the subjects' ability to discriminate tests of relevant from irrelevant information and augmented the heart-rate deceleratory response during presentation of novel stimuli. It was speculated that MSH/ACTH 4-10 has a predominant influence on attentional processes and that it may be uniquely coded for attentional/perceptual functioning.




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Copyright © 1977 by The Endocrine Society