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Cell Biology Laboratory, Endocrine and Metabolism Divisions, Children's Hospital Medical Center, Hematology Division, Peter Bent Brigham Hospital, and the Departments of Pediatrics, Medicine, Orthopedic Surgery, and Biological Chemistry, Harvard Medical School, and the Department of Oral Biology, Harvard School of Dental Medicine, Boston, Boston, Massachusetts
Reprint requests to: Dr. Gabbay, Children's Hospital Medical Center, Boston, Massachusetts 02115.
The glycosylated minor hemoglobin components Hb Ala+b and Hb Alc are elevated in insulin-dependent juvenile diabetic patients, 3.2 ±0.7 (±1 SD) and 10.0±1.9% of total hemoglobin, respectively, versus 2.1 ± 0.4 and 4.9 ± 0.7%in a normal non-diabetic control population. Total glycosylated hemoglobin components, Hb Ala+b+C)correlated with the degree of diabetic blood glucose regulation as measured by antecedent 24-h urinary glucose excretion determined in 220 diabetic patients immediately before, 1, 2, and 3 months prior to the Hb A1a+b+c measurement. This assay for longterm blood glucose regulation was utilized to determine the effect of hyperglycemia on plasma cholesterol levels in 112 diabetic patients. Hb A1a+b+c levels correlated with plasma cholesterol levels, suggesting that long-term hyperglycemia is associated with hypercholesterolemia. It is suggested that glycosylated hemoglobin measurement is a good index of long-term blood glucose levels in diabetic patients.
Supported in part by a grant from the Juvenile Diabetes Foundation, and U.S. Public Health Service Grants (AM-15019, AM-18223, HL-15895, and HL- 20539). Dr. Gabbay is the recipient of an Established Investigatorship of the American HeartAssociation.
Presented in part at the Annual Meeting of the American Diabetes Association, June 21-22, 1976.
Received December 10, 1976.
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