| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Cell Biology Laboratory, Endocrine and Metabolism Divisions, Children's Hospital Medical Center, Hematology Division, Peter Bent Brigham Hospital, and the Departments of Pediatrics, Medicine, Orthopedic Surgery, and Biological Chemistry, Harvard Medical School, and the Department of Oral Biology, Harvard School of Dental Medicine, Boston, Boston, Massachusetts
Reprint requests to: Dr. Gabbay, Children's Hospital Medical Center, Boston, Massachusetts 02115.
The glycosylated minor hemoglobin components Hb Ala+b and Hb Alc are elevated in insulin-dependent juvenile diabetic patients, 3.2 ±0.7 (±1 SD) and 10.0±1.9% of total hemoglobin, respectively, versus 2.1 ± 0.4 and 4.9 ± 0.7%in a normal non-diabetic control population. Total glycosylated hemoglobin components, Hb Ala+b+C)correlated with the degree of diabetic blood glucose regulation as measured by antecedent 24-h urinary glucose excretion determined in 220 diabetic patients immediately before, 1, 2, and 3 months prior to the Hb A1a+b+c measurement. This assay for longterm blood glucose regulation was utilized to determine the effect of hyperglycemia on plasma cholesterol levels in 112 diabetic patients. Hb A1a+b+c levels correlated with plasma cholesterol levels, suggesting that long-term hyperglycemia is associated with hypercholesterolemia. It is suggested that glycosylated hemoglobin measurement is a good index of long-term blood glucose levels in diabetic patients.
Supported in part by a grant from the Juvenile Diabetes Foundation, and U.S. Public Health Service Grants (AM-15019, AM-18223, HL-15895, and HL- 20539). Dr. Gabbay is the recipient of an Established Investigatorship of the American HeartAssociation.
Presented in part at the Annual Meeting of the American Diabetes Association, June 21-22, 1976.
Received December 10, 1976.
This article has been cited by other articles:
 |
|
 |
|
  E S Kilpatrick Haemoglobin A1c in the diagnosis and monitoring of diabetes mellitus J. Clin. Pathol., September 1, 2008; 61(9): 977 - 982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A H Berg and D B Sacks Haemoglobin A1c analysis in the management of patients with diabetes: from chaos to harmony J. Clin. Pathol., September 1, 2008; 61(9): 983 - 987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kahn and V. Fonseca Translating the A1C Assay Diabetes Care, August 1, 2008; 31(8): 1704 - 1707. [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Krishnan, C. S.-Y. Lin, and M. C. Kiernan Activity-dependent excitability changes suggest Na+/K+ pump dysfunction in diabetic neuropathy Brain, May 1, 2008; 131(5): 1209 - 1216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. T. Elia, D. Daneman, J. Rovet, M. Abdolell, W.-C. Lam, C. Till, V. Erraguntla, S. Rubab, N. Lodha, and C. A. Westall Color Visual Evoked Potentials in Children with Type 1 Diabetes: Relationship to Metabolic Control Invest. Ophthalmol. Vis. Sci., November 1, 2005; 46(11): 4107 - 4113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Krishnan and M. C. Kiernan Altered nerve excitability properties in established diabetic neuropathy Brain, May 1, 2005; 128(5): 1178 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Cely, P. Arora, A. A. Quartin, D. H. Kett, and R. M. H. Schein Relationship of Baseline Glucose Homeostasis to Hyperglycemia During Medical Critical Illness Chest, September 1, 2004; 126(3): 879 - 887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E S Kilpatrick HbA1c measurement J. Clin. Pathol., April 1, 2004; 57(4): 344 - 345. [Full Text] [PDF]
|
|
|
|
|
|
E. S Kilpatrick Glycated haemoglobin in the year 2000 J. Clin. Pathol., May 1, 2000; 53(5): 335 - 339. [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Singer, C. M. Coley, J. H. Samet, and D. M. Nathan Tests of Glycemia in Diabetes Mellitus: Their Use in Establishing a Diagnosis and in Treatment Ann Intern Med, January 15, 1989; 110(2): 125 - 137. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Klein, B. E. K. Klein, S. E. Moss, M. D. Davis, and D. L. DeMets Glycosylated Hemoglobin Predicts the Incidence and Progression of Diabetic Retinopathy JAMA, November 18, 1988; 260(19): 2864 - 2871. [Abstract] [PDF]
|
|
|
|
 |
|
 J. A. Ahern, S. Bates, and W. V. Tamborlane Discrepancies Between Blood Glucose and Glycosylated Hemoglobin in Intensively Treated Diabetic Patients The Diabetes Educator, January 1, 1988; 14(1): 30 - 32. [PDF]
|
|
|
|
 |
|
 T. W. Rowland, L. A. Swadba, D. E. Biggs, E. J. Burke, and E. O. Reiter Glycemic Control With Physical Training in Insulin-Dependent Diabetes Mellitus Arch Pediatr Adolesc Med, March 1, 1985; 139(3): 307 - 310. [Abstract] [PDF]
|
|
|
|
 |
|
 E. T. Zawada Jr, M. Johnson, T. Mackenzie, D. A. Sica, W. Muakkassa, S. J. Green, and M. Goldman Hemoglobin A1 in Renal Transplant Recipients Arch Intern Med, January 1, 1985; 145(1): 82 - 84. [Abstract] [PDF]
|
|
|
|
|
|
Glycosylated Hemoglobin Assays in the Management and Diagnosis of Diabetes Mellitus Ann Intern Med, November 1, 1984; 101(5): 710 - 713. [Abstract] [PDF]
|
|
|
|
|
|
C. P. Saucier Improvement in Long-Term Control of Children Performing Blood Glucose Self-Monitoring The Diabetes Educator, September 1, 1984; 10(3): 33 - 35. [PDF]
|
|
|
|
 |
|
 B. C. Lerner, S. D. Varma, and R. D. Richards Polyol Pathway Metabolites in Human Cataracts: Correlation of Circulating Glycosylated Hemoglobin Content and Fasting Blood Glucose Levels Arch Ophthalmol, June 1, 1984; 102(6): 917 - 920. [Abstract] [PDF]
|
|
|
|
|
|
R. L. Jackson, J. A. Esterly, R. A. Guthrie, J. E. Hewett, and H. B. Waiches Capillary Basement Membrane Changes in Adolescents With Type 1 Diabetes JAMA, November 5, 1982; 248(17): 2143 - 2147. [Abstract] [PDF]
|
|
|
|
|
|
J. M. Falko, T. M. O'Dorisio, and S. Cataland Spurious Elevations in Glycosylated Hemoglobin (HbA1) Secondary to Hypertriglyceridemia Arch Intern Med, July 1, 1982; 142(7): 1370 - 1371. [Abstract] [PDF]
|
|
|
|
|
|
A. Lev-Ran Glycohemoglobin: Its Use in the Follow-up of Diabetes and Diagnosis of Glucose Intolerance Arch Intern Med, May 1, 1981; 141(6): 747 - 749. [Abstract] [PDF]
|
|
|
|
|
|
E. B. Rappaport, R. A. Ulstrom, D. D. Etzwiler, D. Fife, B. E. Hedlund, and M. W. Steffes Urine C-peptide, {beta}-Cell Function, and Insulin Requirement Arch Pediatr Adolesc Med, December 1, 1980; 134(12): 1129 - 1133. [Abstract] [PDF]
|
|
|
|
|
|
A. O. Vladutiu Faster Electrophoretic Mobility of Albumin in Diabetes JAMA, July 4, 1980; 244(1): 27 - 28. [Abstract] [PDF]
|
|
|
|
 |
|
 J. R. Williamson and C. Kilo Small-Vessel Disease: Diabetic Microangiopathy Angiology, July 1, 1980; 31(7): 448 - 454. [PDF]
|
|
|
|
|
|
H. E. Oppenheimer An Update on the Diagnosis of Diabetes Angiology, July 1, 1980; 31(7): 455 - 461. [Abstract] [PDF]
|
|
|
|
|
|
G. BODEN, R. W. MASTER, S. S. GORDON, C. R. SHUMAN, and O. E. OWEN Monitoring Metabolic Control in Diabetic Outpatients with Glycosylated Hemoglobin Ann Intern Med, March 1, 1980; 92(3): 357 - 360. [Abstract] [PDF]
|
|
|
|
|
|
J. M. Miller Jr, M. C. Crenshaw Jr, and S. I. Welt Hemoglobin A1c in Normal and Diabetic Pregnancy JAMA, December 21, 1979; 242(25): 2785 - 2787. [Abstract] [PDF]
|
|
|
|
|
|
P. J. DUNN, R. A. COLE, J. S. SOELDNER, and R. E. GLEASON Reproducibility of Hemoglobin AIc and Sensitivity to Various Degrees of Glucose Intolerance Ann Intern Med, September 1, 1979; 91(3): 390 - 396. [Abstract] [PDF]
|
|
|
|
|
|
A. Lev-Ran and W. P. VanderLaan Glycohemoglobins and Glucose Tolerance JAMA, March 2, 1979; 241(9): 912 - 914. [Abstract] [PDF]
|
|
|
|
|
|
R. J. GRAF, J. B. HALTER, E. HALAR, and D. PORTE Jr. Nerve Conduction Abnormalities in Untreated Maturity-Onset Diabetes: Relation to Levels of Fasting Plasma Glucose and Glycosylated Hemoglobin Ann Intern Med, March 1, 1979; 90(3): 298 - 303. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Bunn, K. Gabbay, and P. Gallop The glycosylation of hemoglobin: relevance to diabetes mellitus Science, April 7, 1978; 200(4337): 21 - 27. [Abstract] [PDF]
|
|
|
|
|
|
C. M. PETERSON and R. L. JONES Minor Hemoglobins, Diabetic "Control," and Diseases of Postsynthetic Protein Modification Ann Intern Med, October 1, 1977; 87(4): 489 - 491. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
