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Journal of Clinical Endocrinology & Metabolism, Vol 44, 1010-1013, Copyright © 1977 by Endocrine Society

ARTICLES

Stimulation of growth hormone secretion by desimipramin and chlorimipramin in man

G Laakmann, G Schumacher and O Benkert

In twelve healthy male subjects 75 mg desimipramin (DMI) administered intramuscularly and 100 mg DMI given orally led to a prompt rise in serum growth hormone (GH) levels. The maximum level of serum GH was observed 60 min after the i.m. and 150 min after the oral administration of DMI. Chlorimipramin (CI) administered in the same manner and in the same dosages resulted in a significant increase in GH in only six out of twelve subjects. The maximum level was observed 60 min after the i.m. and 150 min after the oral administration of DMI. There was no change in the prolactin (PRL) levels after administration of DMI and CI.


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[Abstract] [PDF]


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Copyright © 1977 by The Endocrine Society