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STIMULATION OF GROWTH HORMONE SECRETION BY DESIMIPRAMIN AND CHLORIMIPRAMIN IN MAN

Psychiatrische Klinik, Universität München Munich, FRG
Medizinische Klinik Innenstadt, Universität München Munich, FRG

Reprint requests: Dr. G. Laakmann Psychiatrische Klinik Universität München Nussbaumstrasse 7 8000 München 2 Federal Republic of Germany

In twelve healthy male subjects 75 mg desimipramin (DMI) administered intramuscularly and 100 mg DMI given orally led to a prompt rise in serum growth hormone (GH) levels. The maximum level of serum GH was observed 60 min after the i.m. and 150 min after the oral administration of DMI. Chlorimipramin (CI) administered in the same manner and in the same dosages resulted in a significant increase in GH in only six out of twelve subjects. The maximum level was observed 60 min after the i.m. and 150 min after the oral administration of DMI. There was no change in the prolactin (PRL) levels after administration of DMI and CI.

Received January 1, 1977.

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