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Journal of Clinical Endocrinology & Metabolism, Vol 44, 766-770, Copyright © 1977 by Endocrine Society

ARTICLES

Effect of methysergide and pimozide on apomorphine-induced growth hormone secretion in men

S Lal, H Guyda and S Bikadoroff

The dopamine receptor agonist, apomorphine HCl (0.75 mg sc) increased serum growth hormone (GH) concentrations in each of 6 subjects. This increase was not inhibited by pretreatment with the serotonin antagonist, methysergide, but was completely abolished in the 4 individuals pretreated with pimozide, a selective dopamine receptor blocking agent. These results provide further evidence that apomorphine- induced GH secretion is mediated by a dopaminergic mechanism and is independent of a serotonergic mechanism.




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Copyright © 1977 by The Endocrine Society