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Journal of Clinical Endocrinology & Metabolism, Vol 44, 743-747, Copyright © 1977 by Endocrine Society

ARTICLES

Increase in plasma growth hormone levels following thyrotropin- releasing hormone injection in children with primary hypothyroidism

R Collu, G Leboeuf, J Letarte and JR Ducharme

Thyrotropin-releasing hormone (TRH) induced a significant increase in plasma growth hormone (GH) levels in 4 of 8 children with primary hypothyroidism, while a slight decrease was observed in 8 control children. Base-line plasma prolactin (PRL) levels and peak responses to TRH were higher in hypothyroid children than in controls. These data may indicate the existence of dysfunction of central nervous system mechanisms of control of GH and PRL secretion in subjects with primary hypothyroidism.


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R. Collu, J. Tang, J. Castagne, G. Lagace, N. Masson, C. Huot, C. Deal, E. Delvin, E. Faccenda, K. A. Eidne, et al.
A Novel Mechanism for Isolated Central Hypothyroidism: Inactivating Mutations in the Thyrotropin-Releasing Hormone Receptor Gene
J. Clin. Endocrinol. Metab., May 1, 1997; 82(5): 1561 - 1565.
[Abstract] [Full Text] [PDF]


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