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Journal of Clinical Endocrinology & Metabolism, Vol 44, 603-606, Copyright © 1977 by Endocrine Society

ARTICLES

Differential response of serum LH in hypogonadotropic hypogonadism and delayed puberty to LH-RH stimulation before and after clomiphene citrate administration

MC Snoep, WE de Lange, WJ Sluiter and H Doorenbos

The differential diagnosis between hypogonadotropic hypogonadism and delayed puberty is facilitated by comparing the response of gonadotropins to LH-RH stimulation before and after administration of clomiphene citrate 200 mg daily during 7 days. Premedication of clomiphene citrate depresses peak values of LH and FSH on LH-RH in delayed puberty. In hypogonadotropic hypogonadism clomiphene citrate raises LH-RH induced peak LH while FSH does not change.




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Copyright © 1977 by The Endocrine Society