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DIFFERENTIAL RESPONSE OF SERUM LH IN HYPOGONADOTROPIC HYPOGONADISM AND DELAYED PUBERTY TO LH-RH STIMULATION BEFORE AND AFTER CLOMIPHENE CITRATE ADMINISTRATION.

Division of Clinical Endocrinology, Department of Internal Medicine, State University Hospital Groningen, the Netherlands.

The differential diagnosis between hypogonadotropic hypogonadism and delayed puberty is facilitated by comparing the response of gonadotropins to LH-RH stimulation before and after administration of clomiphene citrate 200 mg daily during 7 days. Premedication of clomiphene citrate depresses peak values of LH and FSH on LH-RH in delayed puberty. In hypogonadotropic hypogonadism clomiphene citrate raises LH-RH induced peak LH while FSH does not change.

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