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THE METABOLISM OF [6-³H]1, HYDROXYCHOLECALCIFEROL TO [6-³H]1, 25-DIHYDROXYCHOLECALCIFEROL IN A PATIENT WITH RENAL INSUFFICIENCY

Michael F. Holick, Maria C. de Blanco, Mary B. Clark, John W. Henley^,, Robert M. Neer, Hector F. DeLuca^* and John T. Potts, Jr.

Endocrine Unit, Department of Medicine, Harvard Medical School and the Massachusetts General Hospital Boston, Massachusetts
^* Department of Biochemistry, University of Wisconsin Madison, Wisconsin

To evaluate whether lahydroxycholecalciferol is metabolized to 1, 25-dihydroxycholecalciferol in man, [6-³H]1-hydroxycholecalciferol was given intravenously to a patient with renal failure who was maintained daily on 100, 000 IU vitamin D and calcium supplements. Using Sephadex LH-20 and high-pressure liquid chromatography, it was clearly demonstrated that 1-hydroxycholecalciferol rapidly disappears from the blood and is metabolized to 1, 25-dihydroxycholecalciferol.

This work was supported by N.I.H. Grants AM11794, AM04501, AM17459, and by the John A. Hartford Foundation, Inc.

JWH i s the recipient of a New Zealand M.R.C. Overseas Fellowship.

Received December 9, 1976.

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