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Journal of Clinical Endocrinology & Metabolism, Vol 44, 595-598, Copyright © 1977 by Endocrine Society

ARTICLES

The metabolism of [6-3H]1alpha, hydroxycholecalciferol to [6- 3H]1alpha,25-dihydroxycholecalciferol in a patient with renal insufficiency

MF Holick, MC de Blanco, MB Clark, JW Henley, RM Neer, HF DeLuca and JT Potts Jr

To evaluate whether 1alpha-hydroxycholecalciferol is metabolized to 1alpha,25-dihydroxycholecalciferol in man, [6-3H]1alpha- hydroxycholecalciferol was given intravenously to a patient with renal failure who was maintained daily on 100,000 IU vitamin D and calcium supplements. Using Sephadex LH-20 and high-pressure liquid chromatography, it was clearly demonstrated that 1alpha- hydroxycholecalciferol rapidly disappears from the blood and is metabolized to 1alpha,25-dihydroxycholecalciferol.


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Nephrol. Dial. Transplant., May 1, 2002; 17(5): 829 - 842.
[Abstract] [Full Text] [PDF]


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