This Article Full Text (PDF) Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by KOPP, L. Articles by TUCCI, J. R. Search for Related Content PubMed PubMed Citation Articles by KOPP, L. Articles by TUCCI, J. R.

Urinary Excretion of Cyclic 3', 5'-Adenosine Monophosphate and Cyclic 3', 5'-Guanosine Monophosphate During and After Pregnancy

Department of Medicine, Roger Williams General Hospital, and Division of Biological and Medical Sciences Brown University, Providence, R.I. 02912

Urinary cyclic AMP and cyclic GMP excretions were measured in 24-h urine specimens obtained from 89 women at various times during their normal uncomplicated intrauterine pregnancies and from 49 women at various times after the births of their normal healthy infants. Cyclic AMP excretion increased steadily from the beginning of the second trimester or earlier until late in the third trimester, reaching a peak excretion approximately 40% greater than that of normal nonpregnant women. The cyclic AMP excretion dropped abruptly by the first day after parturition to levels which were not significantly different from those of normal nonpregnant women. In contrast, cyclic GMP excretion increased rapidly during the first trimester and remained relatively constant during the remainder of the pregnancy, reaching a peak excretion of about 140% greater than that of normal nonpregnant women. Furthermore, it decreased slowly toward normal levels, but was still significantly elevated six weeks after parturition. The factors responsible for the increased excretion of cyclic AMP during pregnancy and for the increased cyclic GMP during and after pregnaYicy are not known.

Supported by Grants CA 13943 from the National Cancer Institute, National Institutes of Health, DHEW and IN-45N, Brown University Institutional Research Grant from the American Cancer Society.

Received August 5, 1976.

This article has been cited by other articles:

				L. Zhang, D. Xiao, and X. Hu Effect of cGMP on Pharmacomechanical Coupling in the Uterine Artery of Near-Term Pregnant Sheep J. Pharmacol. Exp. Ther., November 1, 2008; 327(2): 425 - 431. [Abstract] [Full Text] [PDF]

				K. P. Conrad Mechanisms of Renal Vasodilation and Hyperfiltration During Pregnancy Reproductive Sciences, October 1, 2004; 11(7): 438 - 448. [Abstract] [PDF]

				J. M. Davison, V. Homuth, A. Jeyabalan, K. P. Conrad, S. A. Karumanchi, S. Quaggin, R. Dechend, and F. C. Luft New Aspects in the Pathophysiology of Preeclampsia J. Am. Soc. Nephrol., September 1, 2004; 15(9): 2440 - 2448. [Abstract] [Full Text] [PDF]

				L. Brawley, C. Torrens, F. W. Anthony, S. Itoh, T. Wheeler, A. A. Jackson, G. F. Clough, L. Poston, and M. A. Hanson Glycine rectifies vascular dysfunction induced by dietary protein imbalance during pregnancy J. Physiol., January 15, 2004; 554(2): 497 - 504. [Abstract] [Full Text] [PDF]

				I. M. Bird, L. Zhang, and R. R. Magness Possible mechanisms underlying pregnancy-induced changes in uterine artery endothelial function Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R245 - R258. [Abstract] [Full Text] [PDF]

				M. D. Savvidou, P. J.T. Vallance, K. H. Nicolaides, and A. D. Hingorani Endothelial Nitric Oxide Synthase Gene Polymorphism and Maternal Vascular Adaptation to Pregnancy Hypertension, December 1, 2001; 38(6): 1289 - 1293. [Abstract] [Full Text] [PDF]

				D. Xiao, W. J. Pearce, and L. Zhang Pregnancy enhances endothelium-dependent relaxation of ovine uterine artery: role of NO and intracellular Ca2+ Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H183 - H190. [Abstract] [Full Text] [PDF]

				K. P. Conrad, L. J. Kerchner, and M. D. Mosher Plasma and 24-h NOx and cGMP during normal pregnancy and preeclampsia in women on a reduced NOx diet Am J Physiol Renal Physiol, July 1, 1999; 277(1): F48 - F57. [Abstract] [Full Text] [PDF]

				I. Dorup, K. Skajaa, and K. E. Sorensen Normal pregnancy is associated with enhanced endothelium-dependent flow-mediated vasodilation Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H821 - H825. [Abstract] [Full Text] [PDF]