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Hormonal Changes Induced by Bromocriptine (CB-154) at the Early Stage of Treatment

Department of Endocrinology and Metabolism, Hôpital Cochin F 75675 Paris, Cedex 14, France

Fifteen female patients with amenorrhea and hyperprolactinemia were studied 1 to 3 times daily during the first 4 days of treatment with bromocriptine (2.5 mg b.i.d.). Normal PRL levels were reached within one day in 12 while the mean value for the whole group showed no further significant decrease. Estradiol, LH and FSH levels did not vary significantly at this stage even in those 10 patients who subsequently resumed menstruation.

Supported by grants no. 73 2 489 22 CA and 74 7 0809 from l'I.N.S.E.R.M. and the D.G.R.S.T. and by Sandoz Laboratories (France).

Received April 12, 1976.

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