help button home button Endocrine Society JCEM
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Journal of Clinical Endocrinology & Metabolism Vol. 44, No. 3 585-587
doi:10.1210/jcem-44-3-585
Copyright © 1977 by the Endocrine Society.
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by COOPER, D. S.
Right arrow Articles by JACOBS, L. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by COOPER, D. S.
Right arrow Articles by JACOBS, L. S.

Failure of Papaverine to Alter L-Dopa-Influenced GH and PRL Secretion1

DAVID S. COOPER and LAURENCE S. JACOBS

Metabolism Division, Department of Medicine, Washington University St. Louis, Missouri 63110

Papaverine, 150 mg BID for 2 weeks, a dose which produced marked clinical impairment in Parkinsonian patients taking L-Dopa, failed to alter L-Dopa-stimulated GH secretion or L-Dopainhibited PRL secretion in 6 normal volunteers. Failure to demonstrate an inhibitory effect of papaverine on dopaminergic hypothalamic-pituitary systems, despite its inhibition of striatal dopaminergic pathways, may imply qualitative or quantitative functional differences between hypothalamic and striatal dopaminergic systems.

1 Studies supported in part by research grant 5R01-AM05105, Diabetes Center Grant 5P30-AM17904, and -Research Career Development Award 5K04-AM70521 (LSJ) from the National Institute of Arthritis, Metabolism, and Digestive Diseases, and by Clinical Research Center Grant RR00036 from the Division of Research Resources, General Clinical Research Centers Branch, NIH, Bethesda, Maryland.

Received August 10, 1976.







HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1977 by The Endocrine Society